Use

Chronic urticaria (CU) is a common and complex dermatological condition characterized by persistent hives lasting for more than six weeks. This condition is often suspected in patients who do not exhibit symptoms of an exogenous allergen. Approximately 45 percent of CU cases involve autoantibodies that target basophils or mast cell-associated IgE receptors, such as the high-affinity IgE-Fc receptor (Fc epsilon R1 alpha). Evaluating the presence of histamine-releasing factors in patient serum can provide insights into the basophil and mast cell activation status, which can aid in the diagnosis of CU.