Oncology FISH Analysis - STAT Comprehensive MDS/AML FISH Panel
Use
Oncology FISH Analysis – STAT Comprehensive MDS/AML FISH Panel is designed to detect chromosomal abnormalities associated with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) that are significant for diagnosis and prognosis. These disorders primarily affect adults. AML may originate from bone marrow and spread throughout the body, leading to serious complications. MDS could evolve into AML, causing increased susceptibility to infections and bleeding due to dysfunctional blood cell production. This test identifies specific genetic anomalies linked to the efficacy of treatments and patient outcomes, serving as a crucial tool in the context of managing these hematologic malignancies.
Special Instructions
This test is intended for individuals with suspected diagnosis of AML or MDS. It serves as a tool for prognostic assessment, particularly in patients whose previous cytogenetic testing was inconclusive. The results should be interpreted alongside relevant clinical information and are essential in tracking treatment responses.
Limitations
This assay only evaluates specified loci for abnormalities; any deviations in other regions will not be detected. Interpretation of these results must be contextualized and should not serve as the sole basis for clinical decisions. Misguided reliance on isolated data may lead to misdiagnosis or treatment challenges. The precision of the assay also depends on specimen quality and timely transport to ensure sample integrity.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow (Fresh)
Volume
3-5 cc
Minimum Volume
2 cc
Container
Sodium Heparin tube
Collection Instructions
Draw bone marrow in a Sodium Heparin (green-top) tube(s).
Storage Instructions
Ship at ambient temperature (18-25°C/64-77°F) in an insulated container by overnight courier. Specimen should arrive in the laboratory within 48 hrs of collection. Do not heat or freeze.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |