Anti-SAE1 Ab, IgG (RDL)
Also known as: SAE Ab; small ubiquitin-like modifier activating enzyme
Use
Anti-SAE 1 IgG autoantibody can be used to assist in the diagnoses and characterization of a subset of dermatomyositis (DM). It is highly specific for DM (>95%) and is present in 5-8% of the European DM population. Initial disease onset may consist of mild myopathic features with severe skin involvement; however, extensive myalgia and muscle disease with weakness can appear as the disease progresses. It is associated with dysphagia and systemic symptoms (i.e. fevers, weight loss, increased inflammatory markers). In one cohort, an association with ILD and cancer had been found.
Special Instructions
The test is a component of the MyoMarker 3 Plus Profile. It requires serum, separated from cells within one hour of collection and transferred to a plastic transport tube for shipping.
Limitations
This test was developed and its performance characteristics were determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 101220-2
- 101220-2
Result Turnaround Time
7-10 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Gel tube or red-top tube
Collection Instructions
Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.
Storage Instructions
Refrigerate or freeze.
Causes for Rejection
Grossly hemolyzed, bacterial contamination, lipemic, icteric, non-serum specimen types
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 14 days |
| Frozen | 60 days |