Cryoglobulin, Qualitative With Quantitative Reflex
Use
Cryoglobulins may be present in macroglobulinemia of Waldenström, myeloma, chronic lymphocytic leukemia, lupus, chronic active hepatitis, and other viral infections.
Special Instructions
Specimen must be drawn in a prewarmed tube and kept at 37°C while clotting. Separate serum from cells immediately after clot formation and transfer serum into a clean transport tube labeled 'Prewarmed'.
Limitations
The test relies on the visual observation of refrigerated samples, which may introduce variability due to subjective interpretation. Additional confirmatory tests such as immunofixation may be needed for precise classification of cryoglobulin types. Reflex testing involves quantitative measurement, which may be required to interpret positive qualitative results accurately.
Methodology
Other
Biomarkers
LOINC Codes
- 12201-0
- 12201-0
- 15174-6
- 48638-1
Result Turnaround Time
4-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
3 mL
Minimum Volume
2 mL
Container
Red-top tube (no gel)
Collection Instructions
Specimen must be drawn in a prewarmed tube and kept at 37°C while clotting. Separate serum from cells immediately after clot formation (keep at 37°C while clotting), and transfer serum into a clean transport tube. Label transport tube 'Prewarmed.'
Patient Preparation
Patient should be fasting.
Storage Instructions
Room temperature
Causes for Rejection
Specimen not allowed to clot at 37°C; patient not fasting; lipemia; gel-barrier tube used for collection; whole blood received