Cryoglobulin, Qualitative, with Reflex to Quantitative IgA, IgG, and IgM
Also known as: CRYGB QNT
Use
This test aids in the evaluation of patients with conditions such as vasculitis, macroglobulinemia, or multiple myeloma, particularly when symptoms are triggered by exposure to cold. Cryoglobulins are associated with certain plasma cell and lymphoproliferative disorders but can also be seen in collagen vascular diseases, hepatitis C infection, and infections like infectious mononucleosis and cytomegalovirus disease. The qualitative screen identifies the presence of cryoglobulin, and if detected, further quantitative analysis of immunoglobulins IgA, IgG, and IgM is performed, aiding in the differential diagnosis.
Special Instructions
Not provided.
Limitations
The test may not detect cryoglobulins present in very low concentrations or those that do not demonstrate a pronounced cold precipitation. Plasma and samples collected in serum separator tubes are unacceptable, as are grossly hemolyzed or lipemic specimens. Samples frozen after separation from cells or not collected as instructed may provide inaccurate results.
New York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 12203-6 - Cryoglob Ser Ql 3D Cold Inc
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
3 mL
Minimum Volume
1 mL
Container
Plain red tube
Collection Instructions
Draw approximately 7 mL of blood into a prewarmed (37 degrees C) plain red tube. Maintain at 37 degrees C until clotting is complete (up to 1 hour), then separate serum from cells ASAP.
Patient Preparation
Fasting specimen required: Overnight or minimum of 8 hours.
Storage Instructions
Store and transport at room temperature. Refrigeration is also acceptable.
Causes for Rejection
Plasma specimens, serum separator tubes, grossly hemolyzed or lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 1 week |
| Refrigerated | 1 week |
| Frozen | Unacceptable |
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