Cryoglobulin Screen with Reflex to Cryoglobulin Panel
Use
This test is an initial qualitative screen for the presence of cryoglobulins in serum. If cryoglobulins are detected, the reflex panel—including Cryocrit immunofixation, immunodiffusion, and rheumatoid factor—is performed to semi‑quantitate and further characterize the cryoglobulin content, aiding in the diagnosis of cryoglobulinemia, which may be associated with autoimmune disease, infections, or hematologic disorders.
Special Instructions
Not provided.
Limitations
If the sample is not kept at 37 °C during clotting, cryoglobulins may precipitate within the clot and be lost on centrifugation, potentially yielding a false negative result.
Methodology
Immunoassay
Biomarkers
Result Turnaround Time
4-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
3 mL
Minimum Volume
2 mL
Container
red‑top tube (no gel)
Collection Instructions
Allow blood to clot for one (1) hour in a 37 °C water bath, incubator, heat block or heel warmer; after clotting, centrifuge as quickly as possible (not refrigerated), decant all serum into a screw‑cap vial; transport at room temperature.
Patient Preparation
Overnight fasting is required
Other tests from different labs that may be relevant