Hepatitis B Core Antibody, Total With Reflex to IgM
Also known as: anti-HBc, anti-HBc Total and IgM, HBV
Use
This assay can be used as an aid in the diagnosis of individuals with acute or chronic hepatitis B virus (HBV) infection and in the determination of the clinical status of HBV infected individuals in conjunction with other HBV serological markers for the laboratory diagnosis of HBV disease associated with HBV infection. This assay can also be used as an aid in the differential diagnosis in individuals displaying signs and symptoms of hepatitis in whom etiology is unknown. This panel can be used to differentiate between the presence of anti-HBc IgG and IgM.
Special Instructions
Hep B Core AB Total, if positive, will reflex to Hep B Core, IgM at an additional charge. Biotin interference: Patients should stop biotin supplements at least 72 hours prior to sample collection to prevent assay interference.
Limitations
The results from this or any other diagnostic kit should be used and interpreted only in the context of the overall clinical picture. A negative test result does not exclude the possibility of exposure to hepatitis B virus. Levels of anti-HBc may be undetectable both in early infection and late after infection. This qualitative assay cannot correlate reported antibody levels to an endpoint titer. Performance characteristics have not been established for immunocompromised or immunosuppressed patients.
Methodology
Immunoassay (CLIA)
Biomarkers
LOINC Codes
- 13952-7
- 13952-7
- 24113-3
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Gel-barrier tube, red-top tube or serum transfer tube
Collection Instructions
If tube other than a gel-barrier tube is used, transfer separated serum to a screw-cap polypropylene transport tube. Do not freeze gel-barrier tube (pour off serum first).
Patient Preparation
Stop biotin consumption at least 72 hours prior to collection.
Storage Instructions
Room temperature
Causes for Rejection
Not specified
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |