Immunofixation (IFE) and Protein Electrophoresis, Random Urine

Casandra

Casandra Test Code LC87141Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 122390CPT Codes 84156, 84166, 86335

Immunofixation (IFE) and Protein Electrophoresis, Random Urine

Also known as: Bence Jones Protein Identification, Random Urine, Globulins, Random Urine, Myeloma Proteins, Random Urine, Urine Immunofixation for Myeloma Proteins

Clinical Use

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Use

Characterize the species of protein or proteins in cases of proteinuria. Techniques can identify albumin, γ-globulin, γ-globulin fragments (light chains, Bence Jones proteins); of value in the study of monoclonal gammopathies, lymphoproliferative diseases, including lymphoma; special application to multiple myeloma, macroglobulinemia of Waldenström, and amyloidosis; work up monoclonal gammopathy (M-spike)

Special Instructions

The request form for the test should include the patient's age and clinical diagnosis to ensure proper interpretation of results. Ensure collection of first morning urine for the best results, and mix the sample well before submission.

Limitations

While the test can identify various proteins, there might be limitations in the ability to fully characterize or quantify all proteins present in urine. Protein electrophoresis and immunofixation are semi-quantitative techniques that might not detect very low concentration proteins. Additionally, sample quality and volume can affect the accuracy of results.

Test Details