Products of Conception (POC) Profile
Also known as: Placental Tissue, Chromosome Analysis and Histology, Products of Conception, Chromosome Analysis and Histology, Spontaneous Abortion, Chromosome Analysis and Histology
Use
This profile is used to rule out chromosome abnormalities as a cause of miscarriage.
Special Instructions
Not provided.
Limitations
The test has several limitations. Firstly, some products of conception samples may only contain maternal tissue, which could lead to inconclusive results regarding fetal chromosomal abnormalities. It is vital to ensure that an accurate sample is collected. Furthermore, sample viability is crucial for cytogenetic analysis as non-viable tissue could hinder the accurate assessment of chromosomal abnormalities. Additionally, shipping conditions must be controlled to avoid gross contamination and freezing of samples, as these will lead to rejection.
Methodology
Culture-based
Biomarkers
Unknown chromosome
Chromosome
LOINC Codes
- 62361-1 - Cells counted
- 55199-4 - Cells karyotyped.total Bld/T
- 62360-3 - Cells analyzed
- 62358-7 - ISCN band level Ql
- 62356-1 - Chrom analy result (ISCN)
- 62357-9 - Chrom analy overall interp-Imp
- 48002-0 - Genomic source class
- 48672-0 - Clinical cytogeneticist Spec
- 11502-2 - Laboratory report
- 39111-0 - Bdy site
- 92447-2
- 66746-9 - Specimen type
- 56831-1 - Problem associated signs+symptoms
- 22636-5 - Path report.relevant Hx Spec
- 18630-4
- 22637-3 - Path report.final Dx Spec
- 22638-1 - Path report.comments Imp Spec
- 22635-7 - Path report.microscopic Spec Other Stn
- 22634-0 - Path report.gross Spec
- 19139-5 - Pathologist name
- 62364-5 - Test performance info Spec
- 49560-6 - Payment procedure
- 76448-0 - CPT billing code
- 52797-8 - Dx ICD code
Result Turnaround Time
10-15 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (Fresh)
Volume
20-50 mg
Minimum Volume
Not provided
Container
Sterile container with culture media (e.g., HAMS, RPMI), Ringer's lactate or Hank's balanced salt solution
Collection Instructions
Aseptically obtain a small piece of tissue with subepidermal layers. Best results are obtained from placental villi, which remain viable much longer than fetal tissue. If specimen is a product of conception, submit in a sterile tube with culture medium (HAMS, RPMI), Ringer's lactate or Hank's balanced salt solution.
Storage Instructions
Refrigerate. Do not freeze.
Causes for Rejection
Gross contamination; frozen tissue; specimen in fixative
Other tests from different labs that may be relevant
