Products of Conception (POC) Profile

Also known as: Placental Tissue, Chromosome Analysis and Histology, Products of Conception, Chromosome Analysis and Histology, Spontaneous Abortion, Chromosome Analysis and Histology

Clinical Use

Order Test

Use

This profile is used to rule out chromosome abnormalities as a cause of miscarriage.

Special Instructions

Not provided.

Limitations

The test has several limitations. Firstly, some products of conception samples may only contain maternal tissue, which could lead to inconclusive results regarding fetal chromosomal abnormalities. It is vital to ensure that an accurate sample is collected. Furthermore, sample viability is crucial for cytogenetic analysis as non-viable tissue could hinder the accurate assessment of chromosomal abnormalities. Additionally, shipping conditions must be controlled to avoid gross contamination and freezing of samples, as these will lead to rejection.

Test Details

Methodology

Culture-based

Biomarkers

Unknown chromosome

Chromosome

Karyotype

Copy Number Alteration • Categorical (e.g., Positive / Negative / Indeterminate)

LOINC Codes

Result Codes

62361-1 - Cells counted
55199-4 - Cells karyotyped.total Bld/T
62360-3 - Cells analyzed
62358-7 - ISCN band level Ql
62356-1 - Chrom analy result (ISCN)
62357-9 - Chrom analy overall interp-Imp
48002-0 - Genomic source class
48672-0 - Clinical cytogeneticist Spec
11502-2 - Laboratory report
39111-0 - Bdy site
92447-2
66746-9 - Specimen type
56831-1 - Problem associated signs+symptoms
22636-5 - Path report.relevant Hx Spec
18630-4
22637-3 - Path report.final Dx Spec
22638-1 - Path report.comments Imp Spec
22635-7 - Path report.microscopic Spec Other Stn
22634-0 - Path report.gross Spec
19139-5 - Pathologist name
62364-5 - Test performance info Spec
49560-6 - Payment procedure
76448-0 - CPT billing code
52797-8 - Dx ICD code

Result Turnaround Time

10-15 days

Specimen

Tissue (Fresh)

Volume

20-50 mg

Minimum Volume

Not provided

Container

Sterile container with culture media (e.g., HAMS, RPMI), Ringer's lactate or Hank's balanced salt solution

Collection Instructions

Aseptically obtain a small piece of tissue with subepidermal layers. Best results are obtained from placental villi, which remain viable much longer than fetal tissue. If specimen is a product of conception, submit in a sterile tube with culture medium (HAMS, RPMI), Ringer's lactate or Hank's balanced salt solution.