Fecal Globin by Immunochemistry (InSure®)

Also known as: FOBT, Occult Blood, Guaiac, FOB, FIT

Clinical Use

Use

InSure® ONE is a fecal immunochemical test (FIT) that qualitatively detects human hemoglobin from blood in fecal samples to aid in detection of lower gastrointestinal bleeding, including that which may be caused by colorectal cancer, large adenomas, polyps, diverticulitis, or ulcerative colitis. It supports early detection of colorectal cancer and other bleeding-related lower gastrointestinal disorders, with guideline support from organizations such as the American Cancer Society, American College of Gastroenterology, and the US Preventive Services Task Force.([clinical.questdiagnostics.com](https://clinical.questdiagnostics.com/QuestInsureONE?utm_source=openai))

Special Instructions

Not provided.

Limitations

No dietary or medicinal restrictions interfere with this assay, unlike guaiac-based tests. Only a qualitative result is provided, and it does not specify lesion location or quantify bleeding. Not a substitute for colonoscopy following a positive result.([rchsd.org](https://www.rchsd.org/lab-test/fecal-globin-by-immunochemistry-insure-11290/?utm_source=openai))

Test Details

Methodology

Immunoassay (Immunochromatography)

Biomarkers

Fecal Globin

Analyte

Fecal Globin Result

Other • Binary (Detected / Not Detected)

Result Turnaround Time

1 day

Specimen

Stool

Volume

Not provided

Minimum Volume

Not provided

Container

InSure FOBT Test Card

Collection Instructions

Collect stool sample from toilet water by brushing and apply to 1–2 windows on the InSure FOBT test card; brushed onto the test card.

Patient Preparation

No special diet or avoidance of drugs or supplements required.

Causes for Rejection

Stool submitted in any container; InSure FOBT cards with stool applied to the sample windows; any test card with obvious blood present; submitted refrigerated or frozen.