Fibrinogen Activity, Clauss
Also known as: Factor I
Use
Fibrinogen is essential for the formation of a blood clot. Deficiency can produce mild to severe bleeding disorders.
Special Instructions
Not provided.
Limitations
Expected impact by therapeutic levels (potential interference depends upon drug concentration): Warfarin: no effect; Heparin (UFH or LMWH): UFH - no effect, LMWH – normal to falsely low; Dabigatran or Argatroban (Thrombin Inhibitors): no effect or falsely low; Rivaroxaban or Apixaban (Factor Xa Inhibitors): no effect.
Methodology
Other
Biomarkers
Result Turnaround Time
2 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
Not provided
Minimum Volume
0.5 mL if as a single test
Container
One full 3.2% sodium citrate (light blue-top) tube
Collection Instructions
Correct ratio of blood to citrate is critical. Do not overfill or underfill collection tube. Mix by inversion 4 times. Do not pool plasma from multiple tubes.
Causes for Rejection
Gross hemolysis • Clotted
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Non-heparinized patients stable up to 72 hours at room temperature; Heparinized patients stable for 24 hours at room temperature. |
| Frozen | Platelet‑poor plasma frozen –20 °C: 30 days; frozen –70 °C: 6 months |