FISH, B‑Cell Chronic Lymphocytic Leukemia Panel
Also known as: B-CLL
Use
This interphase FISH panel detects recurrent cytogenetic abnormalities in B‑cell chronic lymphocytic leukemia (CLL) that have prognostic significance, including deletions (e.g., 13q14, ATM/11q22, TP53/17p13), trisomy 12, and potentially 6q and IGH translocations. These genomic findings inform risk stratification and management decisions in CLL patients.
Special Instructions
Not provided.
Limitations
FISH is targeted and may miss abnormalities not included in the panel such as complex karyotypes or novel aberrations. Metaphase chromosome analysis may reveal additional important cytogenetic findings not detectable by FISH.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Result Turnaround Time
Not provided.
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL
Minimum Volume
3 mL
Container
Green top (sodium heparin) tube
Collection Instructions
Send whole blood specimen in original tube; do not aliquot; send ambient.
Storage Instructions
Ambient (preferred); may be refrigerated.