Herpes Simplex Virus Type 1 and 2, IHC with Interpretation

Use

For the detection of HSV‑infected tissue. Two serotypes of the herpes simplex virus, HSV‑1 (also known as type 1 or oral) and HSV‑2 (type 2 or genital), can establish lifelong latent infections with sensory ganglia. Periodically, the virus reactivates and can cause recurrent cold sores, encephalitis and eye and genital infections. HSV‑1 usually establishes latency in the trigeminal ganglion, a collection of nerve cells near the ear. From there, it tends to recur on the lower lip or face. HSV‑2 usually resides in the sacral ganglion at the base of the spine. From there, it reiterates in the genital area.