Lp‑PLA2 Activity
Also known as: PAF-AH
Use
Lipoprotein‑associated phospholipase A₂ (Lp‑PLA₂), also known as platelet activating factor acetylhydrolase, is an inflammatory enzyme circulating bound mainly to low‑density lipoproteins and localized in atherosclerotic plaques. Elevated Lp‑PLA₂ activity has been shown to independently predict coronary heart disease and stroke risk in the general population, and measuring Lp‑PLA₂ may support identification of individuals at higher cardiovascular risk, potentially guiding initiation or intensification of risk‑reduction strategies.
Special Instructions
Not provided.
Limitations
Not provided.
Methodology
Automated Analyzer (Clinical Chemistry)
Biomarkers
Lp‑PLA2 Activity
Analyte
Result Turnaround Time
3-6 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Red top tube (no additive)
Collection Instructions
Process by removing or separating serum from red blood cells using standard separation procedures; centrifuge and separate within four hours of venipuncture.
Patient Preparation
Fasting preferred, but not required
Causes for Rejection
Hemolysis; moderate to grossly lipemic; moderate to grossly icteric
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 28 days |
| Refrigerated | 28 days |
| Frozen | 43 days (−20 °C) or 90 days (−70 °C) |
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