Nickel, 24 Hour, Urine
Use
This assay is used for biomonitoring patients for nickel exposure via 24‑hour urine, minimizing diurnal variation and reflecting total body burden of exposure. An elevated result (≥6.0 mcg/24 h) in an adult (≥18 years) suggests possible environmental or occupational exposure; in children (<18 years), reference range is not established.
Special Instructions
Specimen should be collected in an ultraclean manner using a plastic container without a metal cap or glued insert. Collection must occur before or at least 48 hours after gadolinium‑containing contrast media; if gadolinium or iodine contrast has been administered, delay collection for 96 hours.
Limitations
Specimen contamination is a significant concern due to ubiquitous environmental nickel; collection and handling require ultraclean protocols. The assay cannot determine the specific nickel compound responsible for exposure. Interpretation may be confounded by exposure from dialysis and incidental findings in absence of known exposure.
New York Approved
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 5705-9
- 5705-9
Result Turnaround Time
2-8 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
0.55 mL
Minimum Volume
0.35 mL
Container
Clean, plastic aliquot container with no metal cap or glued insert; submission in plastic 10‑mL urine tube
Collection Instructions
Collect 24‑hour urine, refrigerate within 4 hours of completion
Patient Preparation
If gadolinium- or iodine-containing contrast media was administered, delay collection for 96 hours
Storage Instructions
Refrigerated preferred, ambient or frozen acceptable
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 28 days |
| Refrigerated | 28 days |
| Frozen | 28 days |