Phosphatidylserine/Prothrombin (PS/PT) Antibody (IgG)

Also known as: PSPT IgG Antibodies, aPS/PT IgG

Clinical Use

Use

Antiphospholipid Syndrome (APS) is an acquired autoimmune thrombophilia characterized by thrombosis (venous and/or arterial or microvascular) and/or pregnancy loss or morbidity in association with persistent positivity of a heterogeneous group of autoantibodies known as anti‑phospholipid antibodies (aPL). Although not included in the international consensus criteria for APS diagnosis, antibodies directed against a phosphatidylserine/prothrombin complex (PS/PT) have been reported to have a high association with venous thrombosis and obstetric abnormalities, and a high degree of concordance with lupus anticoagulant activity.

Special Instructions

Not provided.

Limitations

Not provided.

Test Details

Methodology

Immunoassay

Biomarkers

Phosphatidylserine‑prothrombin complex Ab.IgG

Analyte

PS/PT Ab (IgG)

Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

LOINC Codes

Result Codes

85359-8 - PS-prothrom cmplx IgG SerPl IA-aCnc

Result Turnaround Time

1-3 days

Specimen

Plasma

Volume

1 mL

Minimum Volume

0.5 mL

Container

plastic vial

Collection Instructions

Platelet‑poor plasma collected in a sodium citrate (light blue‑top) tube; centrifuge 15 minutes at approx. 1500 × g within 60 minutes of collection; transfer avoiding buffy layer; centrifuge again; plasma must be free of platelets (<10,000/mcL).