Herpes Simplex Virus Type 2 (HSV-2), Type-specific Antibodies, IgG

Casandra

Casandra Test Code LC28760Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 164098CPT Code 86696

Herpes Simplex Virus Type 2 (HSV-2), Type-specific Antibodies, IgG

Also known as: HSV-2

Clinical Use

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Use

This test is used to detect IgG antibodies specific to HSV type 2 infection and confirm or rule out possible infection with herpes simplex type 2 virus in prenatal patients in whom HSV 2 infection can cause serious prenatal disease. In a patient with no history of lesion disease, a positive result for this test may be indicative that the primary infection was asymptomatic. The magnitude of the Index Value is not indicative of the amount of antibody present in the patient sample. Once infected by HSV, it is possible for a patient to shed virus without the development of lesions (asymptomatic shedding). This test does not indicate the site of HSV infection. There is a considerable homology between HSV-1 and HSV-2 antigens, so that antibodies formed against either virus are highly cross-reactive. This assay is based on glycoprotein G-2, purified from HSV-2 infected cells, and is specific for type 2 antibodies.

Special Instructions

Not provided.

Limitations

A negative result does not entirely rule out the possibility of HSV 2 infection as individuals may not exhibit detectable IgG antibodies at early acute infection stages. False negatives can occur if the HSV virus is glycoprotein G (gG) deficient. False positives may also occur, warranting repeat testing or alternative methods for verification in certain settings. Results in individuals with immune suppression or HIV, or in neonates, cord blood, and body fluids other than serum and plasma, should be cautiously interpreted. Results should be assessed alongside clinical history and other findings.

Test Details