Cyclic Citrullinated Peptide Antibody, IgG and IgA
Also known as: CCP IGGIGA
Use
This test is a highly specific serologic test used to aid in the diagnosis of rheumatoid arthritis (RA) or undifferentiated inflammatory arthritides. It measures antibodies against cyclic citrullinated peptide (CCP) in both IgA and IgG forms, which enhances the sensitivity for RA diagnosis. The presence of these autoantibodies is associated with future RA development and may predict radiographic joint destruction. They can also be present in the preclinical phase of the disease, providing critical information for patient management.
Special Instructions
Not provided.
Limitations
The test may not identify all cases of rheumatoid arthritis as some patients may not have detectable levels of anti-CCP antibodies. In particular, patients with weak positive results should be monitored over time. False positives may occur, especially in the context of other inflammatory conditions or in the presence of other autoantibodies, leading to misdiagnosis if interpreted in isolation without clinical context.
FDA ApprovedNew York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
Cyclic Citrullinated Peptide
Protein
LOINC Codes
- 57093-7 - cCP IgA+IgG SerPl IA-aCnc
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1.0 mL
Minimum Volume
0.5 mL
Container
Serum separator tube (SST)
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection. Transfer to an ARUP standard transport tube.
Storage Instructions
Refrigerated.
Causes for Rejection
Contaminated, heat-inactivated, grossly hemolyzed, grossly icteric, or grossly lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 30 days (avoid repeated freeze/thaw cycles) |
Other tests from different labs that may be relevant