Anti-CCP (Cyclic Citrullinated Peptide) Antibodies, IgG and IgA, ELISA
Also known as: Anti-CCP, Anti-citrullinated protein antibodies (ACPA), Anti-Cyclic Citrullinated Peptide Ab, Cyclic Citrullinated Peptide Antibody
Use
The presence of CCP antibodies, when considered in conjunction with other laboratory and clinical findings, is an aid in the diagnosis of rheumatoid arthritis (RA). Approximately 70% of RA patients are positive for anti-CCP IgG, while only 2% of random blood donors and control subjects are positive.
Special Instructions
Following collection, serum should be separated from the clot and the sample should be stored at room temperature.
Limitations
The test may yield negative results in early stages of rheumatoid arthritis and may be affected by factors such as hemolysis, lipemia, gross bacterial contamination, the addition of azide or other preservatives, and heat inactivation. Additional confirmatory tests may be required.
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 57093-7
- 57093-7
Result Turnaround Time
2-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL
Container
Red-top tube or gel-barrier tube
Collection Instructions
Following collection, serum should be separated from the clot.
Storage Instructions
Room temperature
Causes for Rejection
Hemolysis; lipemia; gross bacterial contamination; addition of azide or other preservative; heat inactivation
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 14 days |
| Frozen | 14 days |