Anti-CCP (Cyclic Citrullinated Peptide) Antibodies, IgG and IgA (RDL)
Use
Anti-CCP (cyclic citrullinated peptide) antibodies are autoantibodies that are present in patients with established rheumatoid arthritis (RA). These antibodies have a sensitivity of 66-79% in established RA, and 59% in early RA cases. Importantly, Anti-CCP shows higher specificity for the diagnosis of RA compared to Rheumatoid Factor (RF), with a specificity range of 90-96%.
Special Instructions
Not provided.
Limitations
The test exhibits sensitivities of 66-79% in established RA cases and 59% in early RA, with a specificity range of 90-96%. False positives and negatives can occur, and results can be influenced by sample stability and integrity. Gross hemolysis, bacterial contamination, lipemic or icteric specimens, as well as non-serum specimen types can lead to rejections.
Methodology
Immunoassay (ELISA)
Biomarkers
CCP (Cyclic Citrullinated Peptide)
Protein
LOINC Codes
- 57093-7 - cCP IgA+IgG SerPl IA-aCnc
- 57093-7 - cCP IgA+IgG SerPl IA-aCnc
Result Turnaround Time
5-7 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Red-top tube or gel-barrier tube
Collection Instructions
Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.
Storage Instructions
Refrigerate or freeze.
Causes for Rejection
Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 14 days |
| Frozen | 60 days |
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