Humoral Immunity Panel II
Also known as: HUMPAN II
Use
The Humoral Immunity Panel II is used for secondary testing in the evaluation of patients with recurrent and chronic infections where immunoglobulin testing has already been performed. It assesses the humoral immune response to pneumococcal vaccines, such as Pneumovax 23 and the protein-conjugated Prevnar and Vaxneuvance vaccines, by pre- and post-vaccination comparisons. This allows for the evaluation of immune system competence based on age, past exposure, and serotype-specific responses.
Special Instructions
Prevaccination samples should be collected prior to vaccine administration and postvaccination samples should be obtained at least 4 weeks after immunization. Testing of postvaccination samples alone will only provide general immune status. Individual immune response may vary based on several factors including age and vaccine type.
Limitations
The test requires a pre- and postvaccination sample comparison to adequately assess humoral response. The interpretive criteria for responder status include antibody concentration and fold increase post-vaccination, but may vary for individuals with pre-vaccination concentrations above threshold values. The test has not been cleared or approved by the FDA.
New York Approved
Methodology
Immunoassay (Multiplex Protein Panel)
Biomarkers
LOINC Codes
- 13227-4
- 53935-3
- 85954-6
- 86107-0
- 86130-2
- 27118-9
- 86080-9
- 25296-5
- 86169-0
- 85991-8
- 42771-6
- 86147-6
- 30153-1
- 85977-7
- 27395-3
- 86024-7
- 86064-3
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
Not provided
Minimum Volume
0.1 mL/aliquot
Container
Serum separator tube
Collection Instructions
Transfer two 1 mL aliquots of serum to individual ARUP standard transport tubes.
Storage Instructions
Refrigerated.
Causes for Rejection
Plasma.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 60 days (avoid repeated freeze/thaw cycles) |