Streptococcus pneumoniae IgG Antibody (23 Serotypes), MAID
Also known as: Pneumococcal Ab, 23 Serotypes
Use
Quantifies IgG antibody levels to 23 serotypes of Streptococcus pneumoniae; useful for assessing pre-existing immunity or response to vaccination and evaluating humoral immunodeficiencies. Serologic correlates of protection are not fully established; expert guidance suggests thresholds (eg, ≥0.3–0.5 µg/mL for healthy children; ≥1.3 µg/mL for immunocompromised or noninvasive disease). Interpretation must consider individual immune status and vaccination history.
Special Instructions
Not provided.
Limitations
Protective concentrations for each serotype are not defined; IgG quantitation does not measure functional activity such as opsonophagocytosis; results may vary with age, vaccination history, or immune status. Interpretation should be done in context of paired pre/post‑vaccination samples to minimize assay variation.
New York Approved
Methodology
Immunoassay (Multiplex Protein Panel)
Biomarkers
Result Turnaround Time
4-6 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.4 mL
Container
Plastic vial (serum)
Collection Instructions
Draw blood in red‑top or serum separator tube; centrifuge and aliquot serum into plastic vial.
Storage Instructions
Refrigerated after aliquot.
Causes for Rejection
Gross hemolysis; gross lipemia; gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 21 days |
| Frozen | 21 days |