MITF by Immunohistochemistry

Casandra

Casandra Test Code AR07942Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 2011998CPT Code 88342

MITF by Immunohistochemistry

Also known as: MITF IHC

Clinical Use

Order Test

Use

The MITF by Immunohistochemistry test is utilized to detect the expression of the microphthalmia-associated transcription factor (MITF) in tissue samples. MITF is important for the development and function of melanocytes, the cells responsible for pigmentation in the skin, eyes, and hair. This test is often employed in the differential diagnosis of certain types of melanoma and other soft tissue tumors, providing valuable information that can aid in the assessment and classification of pigmented lesions.

Special Instructions

This test is for stain and return (technical) purposes only, meaning ARUP Laboratories will perform the staining and return the slides. It requires formalin-fixed, paraffin-embedded (FFPE) tissue specimens. Recommended submission method is through tissue block or unstained slides using ARUP's tissue transport kit, although it is not mandatory. Contact ARUP Client Services for supplies and further instructions.

Limitations

The test is a laboratory-developed test (LDT), which means it was developed and its performance characteristics were determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration (FDA). As with other immunohistochemistry tests, quality of results can be affected by factors such as fixation quality, antigen retrieval, and endogenous enzyme activities, which might lead to false-negative or false-positive outcomes. This test is intended for clinical purposes under CLIA certification but may lack standardized FDA performance validation.

Test Details

New York Approved