SOX-10, IHC without Interpretation
Also known as: Immuno Histo Chemistry, Histopathology, SOX 10, epithelial-myoepithelial, myoepithelial
Use
SOX‑10 is a nuclear transcription factor involved in neural crest development, melanocytic and schwannian differentiation. It serves as a sensitive and relatively specific marker for melanoma (including desmoplastic melanoma) and schwannian tumors. It is also expressed in nevi and peripheral nerve sheath tumors (e.g., schwannoma, neurofibroma, MPNST) and normal tissues such as Schwann cells, melanocytes, and glandular myoepithelial cells.
Special Instructions
Specimen must be formalin‑fixed, paraffin‑embedded tissue block or unstained slides (1 per test requested plus 3–4 additional unstained 4 µm charged slides). Include surgical pathology report. Transport at room temperature.
Limitations
Not provided.
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Submit formalin‑fixed, paraffin‑embedded tissue block or unstained charged slides (1 per test requested plus 3–4 additional unstained slides cut at 4 µm).
Storage Instructions
Transport at room temperature.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Paraffin block: 5 years; Slides: 45 days |
| Refrigerated | Paraffin block: 5 years; Slides: 45 days |