Oligoclonal Bands in CSF and Serum
Also known as: OLIGOB
Use
May be used in the assessment of multiple sclerosis to detect unique IgG oligoclonal bands in cerebrospinal fluid (CSF) in conjunction with a matched serum specimen. Oligoclonal bands are present in approximately 95% of patients with multiple sclerosis but may also be present in conditions such as viral or bacterial meningoencephalitis, subacute sclerosing panencephalitis, neurosyphilis, Guillain-Barre syndrome, or meningeal carcinomatosis.
Special Instructions
Recommendation is for CSF and serum to be collected within 24 hours of each other. Specimens must be assayed together for interpretation. It is advised to exercise caution when interpreting results if specimens are not collected within the specified timeframe.
Limitations
This test reports only the number of oligoclonal bands. A patient is considered positive for CSF oligoclonal bands if there are two or more bands in the CSF immunoglobulin region that are not present in the serum. The result is considered positive for intrathecal synthesis of immunoglobulin. Matched serum and CSF bands are indicative of a systemic inflammatory process. Approximately 5 percent of patients with clinically definitive multiple sclerosis will have a negative result, and false positives can occur in other inflammatory conditions.
New York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 48668-8
- 49293-4
- 49852-7
- 48668-8
- 49852-7
- 49293-4
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
1.5 mL
Minimum Volume
0.7 mL
Container
ARUP standard transport tube
Collection Instructions
CSF and serum should be collected within 24 hours of each other.
Storage Instructions
Refrigerated
Causes for Rejection
Grossly bloody or hemolyzed specimens or severe lipemia
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Unacceptable |
| Refrigerated | 2 weeks |
| Frozen | 6 months |