Oligoclonal Bands (IgG), (CSF+Blood)
Also known as: O-Bands, Oligos, Oligoclonal Proteins, Serum & CSF
Use
Oligoclonal bands are present in the CSF of more than 85% of patients with clinically definite multiple sclerosis (MS). To distinguish between oligoclonal bands in the CSF due to a peripheral gammopathy and oligoclonal bands due to local production in the CNS, serum and CSF should be tested simultaneously. Oligoclonal bands can however be observed in a variety of other diseases, e.g., subacute sclerosing panencephalitis, inflammatory polyneuropathy, CNS lupus, and brain tumors and infarctions.
Special Instructions
Both CSF & serum are required specimens. It is preferred that the collection date and time be the same for both; however, it is acceptable for them to be drawn within 48 hours of each other. If no serum is supplied, the client will be contacted to confirm the order. CSF collection tube #4 is preferred. Submitting 4th lumbar puncture collection tube minimizes blood contamination.
Limitations
Not provided.
Methodology
Other
Biomarkers
Result Turnaround Time
Not provided.
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
Not provided
Minimum Volume
0.5 mL
Container
sterile screw cap container
Collection Instructions
1 mL CSF submitted in a sterile screw cap container; CSF collection tube #4 is preferred
Storage Instructions
Refrigerate CSF specimens at 2‑8 °C in sterile plastic CSF vial(s) and send refrigerated (cold packs) or freeze at ‑20 °C and send frozen on dry ice
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 8 hours |
| Refrigerated | 20 days |
| Frozen | 30 days |