Use

The Oligoclonal Band Profile is a critical diagnostic tool for assessing multiple sclerosis and other conditions affecting the central nervous system. It involves detecting unique IgG oligoclonal bands in cerebrospinal fluid (CSF) when compared to a matched serum specimen. The presence of oligoclonal bands solely in the CSF suggests local IgG production within the CNS, indicative of multiple sclerosis or other neurological disorders such as viral or bacterial meningoencephalitis, neurosyphilis, and Guillain-Barré syndrome. This test also helps distinguish peripheral from central nervous system sources of IgG synthesis.