Oncology FISH Analysis - Non-small Cell Lung Carcinoma Panel

Clinical Use

Use

Oncology FISH Analysis - Non-Small Cell Lung Carcinoma Panel is a Fluorescence In Situ Hybridization (FISH) test designed to detect common chromosomal abnormalities associated with non-small cell lung cancer (NSCLC) that are of diagnostic and prognostic significance. NSCLC is the most common type of lung cancer and often presents with coughing, fatigue, and other symptoms that may be mistaken for common illnesses. Identification of certain rearrangements in NSCLC can qualify patients for FDA-approved therapies. Results of this test must always be interpreted in the context of relevant clinical and pathological data and should not be used alone for a diagnosis of non-small cell lung cancer.

Special Instructions

For FFPE specimens, ensure fixation in 10% neutral buffered formalin for 6 to 48 hours with adequate volume. This fixation is crucial to avoid false negatives. Additionally, specimens must be transported at ambient temperature and protected from excessive heat. It is essential to include a corresponding surgical pathology report with the specimens.

Limitations

This FISH assay only tests for abnormalities at the listed loci. Abnormalities involving other loci cannot be identified with this assay.

Test Details

Methodology

Chromosomal / Cytogenetics (FISH)

Biomarkers

2 components

Primary Component • FISHFISH Analysis • FISH

Result Turnaround Time

5 days

Specimen

Tissue (FFPE)

Volume

Adequate amount of tumor to be analyzed

Minimum Volume

Not provided

Container

Positively charged slides

Collection Instructions

3 to 5 unstained 5um FFPE tissue on positively charged slides containing adequate amounts of tumor to be analyzed with areas of tumor marked. Please include a copy of corresponding surgical pathology report.