ALK FISH With Reflex to RET and ROS1
Also known as: Non Small Cell Lung Cancer FISH, NSCLC ALK FISH, Oncology FISH
Use
Confirmation/identification of cancer-related alteration in non-small-cell lung cancer. This is a test for the identification of NSCLC patients who may be eligible for treatment.
Special Instructions
Pertinent clinical diagnostic information, including the pathology report documenting pulmonary origin and tumor grade, should be included with the specimen. Additional charges will apply for the embedding process if formalin-fixed tissue is submitted. A negative ALK FISH will reflex to RET and ROS1 FISH.
Limitations
The test will not detect molecular mutations or chromosomal alterations not targeted by the probe included in this profile. Genetic changes other than those assayed here cannot be ruled out based on this testing. Correlation with clinical and pathology findings is suggested for a complete result interpretation. The performance characteristics of this test were determined by Labcorp, and it has not been cleared or approved by the FDA.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
LOINC Codes
- 66746-9
- 64089-6
- 64086-2
- 78233-4
- 78210-2
- 48672-0
Result Turnaround Time
4-7 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Five slides (4- to 5-micron thick sections) on positively charged slides or one paraffin block
Minimum Volume
Four slides (4- to 5-micron thick sections) on positively charged slides or one paraffin block
Container
Paraffin block
Collection Instructions
Utilize sterile technique and Labcorp transport kits when possible.
Storage Instructions
Maintain specimen at room temperature.
Causes for Rejection
Tumor other than lung; use of fixatives other than 10% formalin; improper embedded prep; poor fixation 72 hours; decalcified bones or bone core; absence of tumor or quantity not sufficient for analysis