FISH, ALK 2p23 Rearrangement, Lung Cancer (NSCLC)
Also known as: Non-Small Cell Lung Cancer (NSCLC), Vysis ALK Break Apart FISH Probe Kit, Crizotinib
Use
This test detects rearrangements of the ALK gene (located at 2p23) in non–small-cell lung carcinoma (NSCLC), which are associated with sensitivity to targeted ALK tyrosine kinase inhibitors.
Special Instructions
Not provided.
Limitations
Specimens that are decalcified, improperly fixed or processed, formerly stained slides, or those with degraded nucleic acid may result in test failure or decreased sensitivity. Tissue adequacy and presence of tumor cells are critical for accurate analysis.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Unknown CNV
Copy Number Region
Result Turnaround Time
Not provided.
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
1 block or 3 slides
Container
IHC Specimen Transport kit
Collection Instructions
Lung tissue biopsy, formalin‑fixed, paraffin‑embedded block or charged/+ slides from formalin‑fixed paraffin embedded tissue. Specimen must be fixed in 10% neutral buffered formalin. Fixation between 6 and 48 hours recommended; do not freeze.
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