HLA-A29 Uveitis - Birdshot Chorioretinopathy
Also known as: A*29, A29, Birdshot Retinochoroidopathy, BSRC, HLA A29
Use
Birdshot chorioretinopathy (BSCR) is a rare form of autoimmune uveitis that can lead to severe visual impairment. Greater than 95% of patients diagnosed with BSCR carry the human leukocyte antigen (HLA)A*29 allele of the major histocompatibility complex (MHC). The MHC family of genes code for a highly variable set of cell surface glycoproteins (HLAs) that play a critical role in presenting antigens to T cell receptors to elicit an immune response.
Special Instructions
If you have questions, please call 800-533-1037 (HLA customer service) for assistance selecting the proper HLA test for the patient.
Limitations
The presence of HLA A*29 alone is not sufficient for a diagnosis of Birdshot Chorioretinopathy. Many individuals with HLA A*29 do not have the disease and some patients with the disease do not have HLA A*29. This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.
Methodology
NGS (Targeted)
Biomarkers
LOINC Codes
- 13298-5
- 13298-5
- 49549-9
Result Turnaround Time
3-7 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
7 mL
Minimum Volume
Not provided
Container
Lavender-top (EDTA) tube
Storage Instructions
Maintain whole blood specimen at room temperature.
Causes for Rejection
Hemolysis; clotted specimen