Intrinsic Pathway Coagulation Factor Profile (Esoterix)
Use
The Intrinsic Pathway Coagulation Factor Profile (Esoterix) is designed to evaluate the activity levels of factors within the intrinsic pathway of coagulation. This test is vital for diagnosing and monitoring bleeding disorders such as hemophilia. By assessing the activity of Factor VIII, IX, XI, and XII, clinicians can gain insights into potential deficiencies or dysfunctions that might affect coagulation and lead to clinical manifestations of bleeding disorders. This is particularly relevant for managing patients with known coagulation deficiencies or those presenting with unexplained bleeding or prolonged clotting times.
Special Instructions
It is important to collect the plasma sample in a blue-top tube containing sodium citrate as an anticoagulant. Plasma must be separated from cells within 45 minutes of collection to ensure sample integrity. For multiple tests requiring frozen samples, separate specimens should be submitted to avoid processing delays.
Limitations
This test specifically measures the activity levels of factors within the intrinsic coagulation pathway and does not assess the extrinsic or common coagulation pathways. It requires careful sample handling, as delays in plasma separation or improper freezing can lead to inaccurate results. Furthermore, results may be affected by pre-existing conditions and medications that alter coagulation factor levels, such as anticoagulants.
Methodology
Other
Biomarkers
LOINC Codes
- 3187-2
- 3209-4
- 3226-8
- 3232-6
- 3209-4
- 3187-2
- 3226-8
- 3232-6
Result Turnaround Time
3-7 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
Two tubes of 1 mL each
Minimum Volume
1.5 mL
Container
Blue-top (sodium citrate) tube
Collection Instructions
Plasma must be separated from cells within 45 minutes of venipuncture. Send plasma in a plastic transport tube. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Storage Instructions
Freeze