Intrinsic Pathway Coagulation Factor Profile (Esoterix)

Clinical Use

Use

The Intrinsic Pathway Coagulation Factor Profile (Esoterix) is designed to evaluate the activity levels of factors within the intrinsic pathway of coagulation. This test is vital for diagnosing and monitoring bleeding disorders such as hemophilia. By assessing the activity of Factor VIII, IX, XI, and XII, clinicians can gain insights into potential deficiencies or dysfunctions that might affect coagulation and lead to clinical manifestations of bleeding disorders. This is particularly relevant for managing patients with known coagulation deficiencies or those presenting with unexplained bleeding or prolonged clotting times.

Special Instructions

Not provided.

Limitations

This test specifically measures the activity levels of factors within the intrinsic coagulation pathway and does not assess the extrinsic or common coagulation pathways. It requires careful sample handling, as delays in plasma separation or improper freezing can lead to inaccurate results. Furthermore, results may be affected by pre-existing conditions and medications that alter coagulation factor levels, such as anticoagulants.

Test Details

Methodology

Other

Biomarkers

4 targets

Factor IXFactor VIIIFactor XIFactor XII

LOINC Codes

Order Codes

3187-2 - Fact IX Act/Nor PPP
3209-4 - Fact VIII Act/Nor PPP
3226-8 - Fact XI Act/Nor PPP
3232-6 - Fact XII Act/Nor PPP

Result Codes

3209-4 - Fact VIII Act/Nor PPP
3187-2 - Fact IX Act/Nor PPP
3226-8 - Fact XI Act/Nor PPP
3232-6 - Fact XII Act/Nor PPP

Result Turnaround Time

3-7 days

Specimen

Plasma

Volume

Two tubes of 1 mL each

Minimum Volume

1.5 mL

Container

Blue-top (sodium citrate) tube

Collection Instructions

Plasma must be separated from cells within 45 minutes of venipuncture. Send plasma in a plastic transport tube. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.