Pre-Biologic Screening Profile
Also known as: Humira; Adalimumab; Remicade; Infliximab; Entyvio; Vedolizumab; Enbrel; Etanercept; Cimzia; Certolizumab; Simponi; Golimumab; Rituxan; Rituximab; Stelara; Ustekinumab; Inflectra; Infliximab-dyyb; Renflexis; Infliximab-abda
Use
Biologic therapies can be used to treat many different autoimmune diseases, such as Inflammatory Bowel Disease, Rheumatoid Arthritis, and Psoriasis. Biologic therapies can be life-changing drugs but they can also suppress the immune system and put the patient at risk of infection. Because of this risk, it is recommended by the American Academy of Dermatology (AAD), American College of Gastroenterology (ACG) and the American College of Rheumatology (ACR) to screen patients for certain infectious diseases, including hepatitis B, hepatitis C and tuberculosis.1-3
Special Instructions
For HCV Antibody Cascade (PCR/Geno) [144127]: Submit two samples, preferably one refrigerated unopened gel-barrier tube and one frozen serum pour off tube. Patients should cease biotin supplementation at least 72 hours prior to collection.
Limitations
Patients negative for HBsAg may still have hepatitis B during the window period. False negatives for M. tuberculosis infection can occur due to incorrect assay performance or other individual immunological variables. Serologic testing should include multiple markers to avoid misinterpretation due to serologic subtypes and other complicating factors.
Methodology
Other
Biomarkers
LOINC Codes
- 144441
- 5196-1
- 13952-7
- 16935-9
- 13955-0
- 8251-1
- 71773-6
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
Two 10 mL gel-barrier tubes
Minimum Volume
Two 10 mL gel-barrier tubes
Container
Two 10 mL gel-barrier tubes
Storage Instructions
Refrigerate 1 gel-barrier tube; maintain 1 gel-barrier tube at room temperature; freeze 4.5 mL serum transfer tube; maintain QuantiFERON-TB Gold Plus kit at room temperature.
Causes for Rejection
Expired collection tubes, centrifuged, refrigerated, or frozen specimens, specimens more than 14 hours old on receipt.