PrEP Use Only: RPR With Reflex to Titer and Treponemal Antibodies
Also known as: Pre-exposure prophylaxis RPR w/reflex to TPAb
Use
This test can be used to screen individuals who are eligible for or who are receiving pre-exposure prophylaxis for HIV (PrEP) for syphilis infection. This test aligns with the CDC-supported traditional serologic testing algorithm for syphilis using a combination of both treponemal and nontreponemal antibody tests. The traditional syphilis testing algorithm begins with the RPR (nontreponemal) test with positive samples reflexing to RPR titer and treponemal antibody testing. Interpretation of results obtained must take into account patient symptoms and clinical history.
Special Instructions
Not provided.
Limitations
Biological false positive results (RPR-reactive, treponemal antibody-negative) can occur due to infections other than syphilis, recent immunization, autoimmune disorders, pregnancy, and injection drug use.
Methodology
Immunoassay (Other)
Biomarkers
RPR
AnalyteRPR Titer
AnalyteTreponemal Antibodies
Analyte
LOINC Codes
- 20507-0 - RPR Ser Ql
- 20507-0 - RPR Ser Ql
- 31147-2 - RPR Ser-Titr
- 47236-5 - T palldm IgG+IgM SerPl Ql IA
- 93479-4 - Observation Imp
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 mL
Minimum Volume
1 mL
Container
Red-top tube or gel-barrier tube
Storage Instructions
Room temperature
Causes for Rejection
Hemolysis; lipemia; gross bacterial contamination; plasma specimen
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |
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