PrEP Use Only: RPR With Reflex to Titer and Treponemal Antibodies

Casandra

Casandra Test Code LC55334Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 006403CPT Code 86592

PrEP Use Only: RPR With Reflex to Titer and Treponemal Antibodies

Also known as: Pre-exposure prophylaxis RPR w/reflex to TPAb

Clinical Use

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Use

This test can be used to screen individuals who are eligible for or who are receiving pre-exposure prophylaxis for HIV (PrEP) for syphilis infection. This test aligns with the CDC-supported traditional serologic testing algorithm for syphilis using a combination of both treponemal and nontreponemal antibody tests. The traditional syphilis testing algorithm begins with the RPR (nontreponemal) test with positive samples reflexing to RPR titer and treponemal antibody testing. Interpretation of results obtained must take into account patient symptoms and clinical history.

Special Instructions

PrEP use only. Contains CPT code modifier for CARES Act. Reactive samples reflex to RPR Titer and Treponemal Antibody testing at an additional charge.

Limitations

Biological false positive results (RPR-reactive, treponemal antibody-negative) can occur due to infections other than syphilis, recent immunization, autoimmune disorders, pregnancy, and injection drug use.

Test Details