Rapid Plasma Reagin (RPR) with Reflex to Titer and FTA-ABS
Also known as: RPR FTA
Use
This test is used for the detection of syphilis infection. It involves an initial screening with the Rapid Plasma Reagin (RPR) test, which is a non-treponemal test used to detect reagin antibodies associated with syphilis infection. If the RPR test is reactive, the test reflexes to a titer and confirmation using the fluorescent treponemal antibody absorption (FTA-ABS) test. This helps in distinguishing between active infection and past treated infections.
Special Instructions
It is advised to use the Rapid Plasma Reagin (RPR) with Reflex to Titer and TP-PA Confirmation (0050478) for an optimal reflex test instead of this test.
Limitations
The RPR test may give false-negative results during early syphilis or in cases of prozone phenomenon. It may also yield false positives in conditions like pregnancy, autoimmune diseases, and other infections. The FTA-ABS test, while more specific, may not differentiate between active and past infections. Patients with past treated syphilis may remain positive for years.
New York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 20507-0
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP standard transport tube
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection.
Storage Instructions
Refrigerated.
Causes for Rejection
Contaminated, grossly hemolyzed, grossly lipemic, plasma, CSF, cord blood, or other body fluids.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year |