Protein Electrophoresis, Cerebrospinal Fluid
Also known as: CSF Electrophoresis, Electrophoresis, CSF, Globulins, CSF, Spinal Fluid Electrophoresis
Use
Quantitate CSF protein fractions; aid in the diagnosis of inflammatory and demyelinating disease of CNS, although routine CSF protein electrophoresis is highly insensitive and nonspecific for the presence of multiple sclerosis (MS). Routine CSF protein electrophoresis has no role in screening for demyelinating diseases (eg, MS). For this, high-resolution electrophoresis is required. For tests with greater sensitivity/specificity for MS, see Oligoclonal Banding [019216].
Special Instructions
Not provided.
Limitations
Routine CSF protein electrophoresis is not a reliable screening tool for demyelinating diseases such as multiple sclerosis due to its insensitivity and nonspecificity. It may not adequately detect slight changes in protein distributions nor differentiate between normal and abnormal patterns in some clinical conditions.
Methodology
Other
Biomarkers
LOINC Codes
- 24352-7 - Prot Elph Pnl CSF
- 2880-3 - Prot CSF-mCnc
- 13973-3 - Prealb MFr CSF Elph
- 13974-1 - Albumin MFr CSF Elph
- 13972-5 - Alpha1 Glob MFr CSF Elph
- 13975-8 - Alpha2 Glob MFr CSF Elph
- 13976-6 - B-Globulin MFr CSF Elph
- 13977-4 - Gamma glob MFr CSF Elph
- 12782-9 - Oligoclonal Bands CSF Elph-Imp
Result Turnaround Time
4-7 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
2 mL
Minimum Volume
1.2 mL
Container
Sterile tube
Collection Instructions
The third tube of a routinely obtained three-tube set of CSF should be used for protein electrophoretic study.
Storage Instructions
Refrigerate at 2°C to 8°C.
Causes for Rejection
Gross hemolysis
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 3 days |
| Frozen | 1 month |
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