Protein Electrophoresis, Random Urine With Reflex to IFE, Random Urine
Also known as: Electrophoresis, Protein, Random Urine With Reflex to IFE, Urine
Use
Work up myeloma, macroglobulinemia of Waldenström, lymphoma, amyloidosis; differentiate between normal renal function, glomerular proteinuria, and tubular proteinuria. Increased glomerular permeability leads to higher concentrations of large proteins in the glomerular filtrate. Diminished tubular reabsorptive capacity results in a marked increase in urinary excretion of low molecular weight problems.
Special Instructions
For 24-hour urine specimens, order test 123018. A serum protein electrophoresis should be reviewed concurrently if one has not been recently studied. Contamination of the urine with blood can give a similar pattern to that of serum.
Limitations
This test may not detect pathologic light chains due to insufficient sensitivity and should be followed with immunoelectrophoretic or immunofixation study performed on concentrated urine. The optimal specimen for detecting free monoclonal light chains (Bence Jones protein) is a 24-hour urine collection. In nonselective glomerular proteinuria, the electrophoretic pattern can be nonspecific, resembling a mirror image of serum patterns.
Methodology
Other
Biomarkers
LOINC Codes
- 2888-6
- 2888-6
- 13992-3
- 13990-7
- 13993-1
- 13994-9
- 13995-6
- 42483-8
- 77202-0
- 13440-3
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
20-mL aliquot
Minimum Volume
11-mL aliquot
Container
12-mL plastic transport tube (Labcorp No. 23597) without preservative
Collection Instructions
Collect first morning urine; mix well.
Storage Instructions
Refrigerated (preferred) or room temperature
Causes for Rejection
Preservative added
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |