Protein, Total, Quantitative, 24-Hour Urine

Clinical Use

Use

Evaluate proteinuria (eg, following urinalysis in which proteinuria is detected); evaluate renal diseases, including proteinuria complicating diabetes mellitus, the nephrotic syndromes (eg, lipoid nephrosis, membranous proliferative glomerulopathies, metal poisoning (eg, gold, lead, and cadmium), renal vein thrombosis, systemic lupus erythematosus (SLE), constrictive pericarditis and amyloidosis); work up other renal diseases including malignant hypertension, glomerulonephritis, Goodpasture syndrome, Henoch-Schönlein purpura, thrombotic thrombocytopenic purpura, collagen diseases, cryoglobulinemia, toxemia of pregnancy, drug nephrotoxicity, hypersensitivity reactions, allergic reactions and renal tubular lesions; manage myeloma and macroglobulinemia of Waldenström (Bence Jones proteinuria); evaluate hypoproteinemia; tubular proteinurias include Wilson's disease and Fanconi syndrome.

Special Instructions

Not provided.

Limitations

Proteinuria can fluctuate, and methods vary in sensitivity to different protein types, with varying results. Collection errors in 24-hour urine collections and calculation errors in laboratory methods may occur. Certain medications and contrast media can cause false positives, and color interference is possible with some substances like Pyridium.

Test Details

Methodology

Automated Analyzer (Clinical Chemistry)

Biomarkers

Protein, Total

Analyte

Protein, Total

Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

LOINC Codes

Order Codes

2889-4 - Prot 24h Ur-mRate

Result Codes

2888-6 - Prot Ur-mCnc
2889-4 - Prot 24h Ur-mRate

Result Turnaround Time

1 day

Specimen

Urine

Volume

50 mL aliquot of entire collection

Minimum Volume

1.0 mL

Container

Plastic urine container, no preservative

Collection Instructions

Instruct patient to void at 8 AM and discard the specimen. Then collect all urine including the final specimen voided at the end of the 24-hour collection period (ie, 8 AM the following day). Mix well. Screw the lid on securely. Container must be labeled with patient's name and date and time collection started and finished.