Protein, Total, Quantitative, 24-Hour Urine
Use
Evaluate proteinuria (eg, following urinalysis in which proteinuria is detected); evaluate renal diseases, including proteinuria complicating diabetes mellitus, the nephrotic syndromes (eg, lipoid nephrosis, membranous proliferative glomerulopathies, metal poisoning (eg, gold, lead, and cadmium), renal vein thrombosis, systemic lupus erythematosus (SLE), constrictive pericarditis and amyloidosis); work up other renal diseases including malignant hypertension, glomerulonephritis, Goodpasture syndrome, Henoch-Schönlein purpura, thrombotic thrombocytopenic purpura, collagen diseases, cryoglobulinemia, toxemia of pregnancy, drug nephrotoxicity, hypersensitivity reactions, allergic reactions and renal tubular lesions; manage myeloma and macroglobulinemia of Waldenström (Bence Jones proteinuria); evaluate hypoproteinemia; tubular proteinurias include Wilson's disease and Fanconi syndrome.
Special Instructions
Indicate the 24-hour urine volume on the request form and urine container, if applicable.
Limitations
Proteinuria can fluctuate, and methods vary in sensitivity to different protein types, with varying results. Collection errors in 24-hour urine collections and calculation errors in laboratory methods may occur. Certain medications and contrast media can cause false positives, and color interference is possible with some substances like Pyridium.
Methodology
Automated Analyzer (Clinical Chemistry)
Biomarkers
LOINC Codes
- 2889-4
- 2888-6
- 2889-4
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
50 mL aliquot of entire collection
Minimum Volume
1.0 mL
Container
Plastic urine container, no preservative
Collection Instructions
Instruct patient to void at 8 AM and discard the specimen. Then collect all urine including the final specimen voided at the end of the 24-hour collection period (ie, 8 AM the following day). Mix well. Screw the lid on securely. Container must be labeled with patient's name and date and time collection started and finished.
Storage Instructions
Room temperature
Causes for Rejection
Grossly bloody specimen; incomplete collection; specimen containing Pyridium®; pH <3
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |