Herpes Simplex Virus Type 1 (HSV-1), Type-specific Antibodies, IgG

Casandra

Casandra Test Code LC19249Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 164897CPT Code 86695

Herpes Simplex Virus Type 1 (HSV-1), Type-specific Antibodies, IgG

Clinical Use

Use

Qualititative detection of IgG antibodies specific to HSV type 1 infection; confirm or rule out possible infection with herpes simplex type 1 virus in prenatal patients. In a patient with no history of lesion disease, a positive result for this test may be indicative that the primary infection was asymptomatic. Once infected by HSV, it is possible for a patient to shed virus without the development of lesions (asymptomatic shedding). This test does not indicate the site of HSV infection. The magnitude of the Index Value is not indicative of the amount of antibody present in the patient sample.

Special Instructions

The test results may not determine the state of active lesions or associated disease manifestations, particularly in primary infection. The predictive value of positive and negative results depends on population prevalence and pretest likelihood of HSV-1. There is considerable homology between HSV-1 and HSV-2 antigens, causing crossreactivity in antibodies. Testing schedule may vary; additional time could be needed for confirmatory tests.

Limitations

A negative test result does not rule out an HSV-1 infection. Individuals may not have detectable IgG antibodies in the early stages of infection. False negatives may occur if the HSV virus is glycoprotein G-deficient. Results in patients with immunosuppressive conditions should be interpreted with caution. Specimens from neonates, cord blood, pretransplant patients or body fluids other than serum and plasma have not been tested. Results should be considered alongside the patient's medical history and clinical examination.

Test Details