Anaplasma phagocytophilum (HGA) Antibodies, IgG and IgM
Also known as: HGE G/M
Use
This test is used for the detection of IgG and IgM antibodies against Anaplasma phagocytophilum, useful for diagnosing acute or convalescent phases of infection, especially when PCR testing is not feasible, like when the infection is outside the acute phase's two-week window. Anaplasma phagocytophilum, the causative agent of human granulocytic anaplasmosis (HGA), is transmitted by tick bites. Detecting antibodies can help confirm a diagnosis in patients with clinical and epidemiological suspicion of tick-borne disease.
Special Instructions
Parallel testing is preferred, and convalescent specimens must be received within 30 days from receipt of acute specimens. Mark specimens plainly as 'acute' or 'convalescent.'
Limitations
This test has not been cleared or approved by the FDA and is performed in a CLIA-certified laboratory for clinical purposes. A positive IgM result alone might not confirm the disease; testing of both acute and convalescent specimens is recommended. Co-infection with Lyme Disease and/or Babesiosis should be considered. The sensitivity and specificity of the test can be influenced by timing of specimen collection and the patient's immune response.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
LOINC Codes
- 23877-4
- 23878-2
Result Turnaround Time
1-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.4 mL
Container
ARUP standard transport tube
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection. Parallel testing is preferred, and convalescent specimens must be received within 30 days from receipt of acute specimens. Mark specimens plainly as 'acute' or 'convalescent.'
Storage Instructions
Refrigerated
Causes for Rejection
Bacterially contaminated, heat-inactivated, hemolyzed, icteric, lipemic, or turbid specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year |