Ehrlichia chaffeensis Antibodies (IgG, IgM)
Use
Human Monocytic Ehrlichiosis (HME) is a tick‑borne infection caused by Ehrlichia chaffeensis. Infections range in severity from asymptomatic to life‑threatening, especially in immunocompromised patients. This serologic assay (IFA) detects IgG and IgM antibodies to aid in the diagnosis of ehrlichiosis, recognizing that early acute illness may show negative titers and paired serologic testing may be warranted for confirmation.
Special Instructions
Set up on Tuesday through Saturday; report usually available next day after receipt, with potential additional time for transport. Perform assay using indirect fluorescent antibody (IFA).
Limitations
Negative results may occur in the first week of illness; single acute titers are insufficient to confirm infection—paired acute and convalescent sera (2‑10 weeks apart) are recommended. IgM is not a reliable indicator of recent infection and remains elevated for months, limiting specificity. Cross‑reactivity and persistence of antibodies may confound interpretation.
Methodology
Immunoassay (Other)
Biomarkers
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.2 mL
Container
Plastic screw‑cap vial
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 14 days |
| Frozen | 30 days |