Chromosome Analysis, Bone Marrow with Reflex to Genomic Microarray
Also known as: BM REFLEX
Use
This test is used for the diagnosis, prognosis, and monitoring of hematopoietic neoplasms such as acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), myelodysplastic syndromes, and chronic lymphocytic leukemia (CLL). Chromosome analysis provides a karyotype that detects chromosomal abnormalities, which can inform clinical management and treatment plans. If the initial karyotype result is normal or indicates no growth, reflex genomic microarray testing is performed to identify additional genomic alterations. These tests together provide a comprehensive genomic profile that aids in clinical decision-making and risk stratification.
Special Instructions
Not provided.
Limitations
The limitations of this test include potential issues such as the inability to provide structural or positional information related to genomic imbalance. Additional testing using methods like FISH may be recommended for more detailed analyses. The test may not detect certain alterations, such as CNVs below the platform's resolution limit, sequence-level variants, low-level mosaicism, and balanced chromosomal rearrangements. These limitations can affect the ability to fully characterize some genetic conditions.
Methodology
Chromosomal / Cytogenetics (Giemsa Band)
Biomarkers
Result Turnaround Time
3-9 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
3 mL
Minimum Volume
0.5 mL
Container
green (sodium heparin) tube
Collection Instructions
Nondiluted bone marrow aspirate collected in a heparinized syringe.
Storage Instructions
Do not freeze or expose to extreme temperatures. Transport at room temperature.
Causes for Rejection
Clotted specimens
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 48 hours |
| Frozen | Unacceptable |
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