Ki-67, MIB-1, by Immunohistochemistry

Also known as: MIB1 IHC

Clinical Use

Use

The Ki-67, MIB-1 test by Immunohistochemistry is used for assessing the proliferation activity of cells in tissue samples, which is crucial for evaluating cancer growth and prognosis. Ki-67 is a cellular marker for proliferation, and its expression is correlated with the aggressiveness of certain tumors, such as those in breast cancer. This analysis plays a significant role in determining appropriate treatment strategies and predicting patient outcomes.

Special Instructions

Not provided.

Limitations

This test is a technical (stain and return) service only, and it has not been cleared or approved by the US Food and Drug Administration. It is performed in a CLIA certified laboratory for clinical purposes, but it should not be used as the sole basis for diagnosis. The performance characteristics of the test were determined by ARUP Laboratories and may not be comparable to other laboratories. Frozen specimens are unacceptable.

Test Details

New York Approved

Methodology

Immunoassay (IHC)

Biomarkers

Ki-67

Protein

IHC

Expression • Categorical (e.g., Positive / Negative / Indeterminate)

LOINC Codes

Result Codes

94736-6 - Tissue block ID Spec
29593-1 - Ki-67 nuclear Ag NFr Tiss ImStn

Result Turnaround Time

1-3 days

Specimen

Tissue (FFPE)

Volume

Not provided

Minimum Volume

2 slides

Container

Tissue transport kit (ARUP supply #47808)

Collection Instructions

Formalin fix (10 percent neutral buffered formalin) and paraffin embed specimen. Cells must be prepared into a cellblock. Protect paraffin block and/or slides from excessive heat. Transport tissue block or 5 unstained (3- to 5-micron thick sections), positively charged slides.