Ki-67, MIB-1, by Immunohistochemistry
Also known as: MIB1 IHC
Use
The Ki-67, MIB-1 test by Immunohistochemistry is used for assessing the proliferation activity of cells in tissue samples, which is crucial for evaluating cancer growth and prognosis. Ki-67 is a cellular marker for proliferation, and its expression is correlated with the aggressiveness of certain tumors, such as those in breast cancer. This analysis plays a significant role in determining appropriate treatment strategies and predicting patient outcomes.
Special Instructions
IMMUNOHISTOCHEMISTRY ORDERING AND SUBMISSION DETAILS: Submit electronic request. If you do not have electronic ordering capability, use an ARUP Immunohistochemistry Stain Form (#32978) with an ARUP client number. For additional technical details, contact ARUP Client Services at (800) 522-2787. Specimen transport kits are available online or through ARUP Client Services.
Limitations
This test is a technical (stain and return) service only, and it has not been cleared or approved by the US Food and Drug Administration. It is performed in a CLIA certified laboratory for clinical purposes, but it should not be used as the sole basis for diagnosis. The performance characteristics of the test were determined by ARUP Laboratories and may not be comparable to other laboratories. Frozen specimens are unacceptable.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
LOINC Codes
- 94736-6
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
2 slides
Container
Tissue transport kit (ARUP supply #47808)
Collection Instructions
Formalin fix (10 percent neutral buffered formalin) and paraffin embed specimen. Cells must be prepared into a cellblock. Protect paraffin block and/or slides from excessive heat. Transport tissue block or 5 unstained (3- to 5-micron thick sections), positively charged slides.
Storage Instructions
Room temperature or refrigerated. Ship in a cooled container during summer months.
Causes for Rejection
Specimens submitted with non-representative tissue type. Depleted specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Indefinitely |
| Refrigerated | Indefinitely |
| Frozen | Unacceptable |