Oncology FISH Analysis - MALT1 Lymphoma
Use
This test is designed to detect chromosomal abnormalities associated with translocations of the MALT1 gene at 18q21 to the API2 gene at 11q21 or the IGH gene at 14q32, which are significant in the prognosis of mucosa-associated lymphoid tissue lymphoma. It is beneficial for patients with a clinical or suspected diagnosis of MALT lymphoma, providing a method to identify prognostic anomalies when cytogenetic testing is not successful. It's important to note that the results should be interpreted alongside relevant clinical and pathological data, and should not be used solely for diagnostic purposes.
Special Instructions
Test requests require completion of the Oncology Kit Order Form. Ensure specimens are collected and sent using appropriate shipping containers to maintain integrity. When shipping, it's crucial to follow specified temperature conditions to ensure that samples reach the laboratory within the required timeframe. Coordinate with laboratory staff for further test-specific inquiries.
Limitations
This FISH assay can determine gain, loss, or break at the MALT1 loci, but it cannot specify the partner chromosome involved in a potential translocation. This limitation is crucial in understanding that while abnormalities can be flagged, complete mapping of all involved chromosomes cannot be determined from this analysis.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Result Turnaround Time
5 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow (Fresh)
Volume
3-5 cc
Minimum Volume
3 cc
Container
Sodium Heparin (green-top) tube
Collection Instructions
Draw bone marrow in a Sodium Heparin (green-top) tube(s).
Storage Instructions
Ship at ambient temperature (18-25C/64-77F) in an insulated container by overnight courier.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hrs |
Other tests from different labs that may be relevant