Oncology FISH Analysis - STAT MDS FISH Panel
Use
Oncology FISH Analysis - STAT MDS is a Fluorescence In Situ Hybridization (FISH) test tailored to identify chromosomal abnormalities linked with myelodysplastic syndrome (MDS). MDS comprises a constellation of myeloid disorders that can lead to bone marrow dysfunction and dysplasia. This analysis is crucial, as specific abnormalities detected can inform both diagnosis and prognosis. For instance, certain abnormalities might suggest a favorable prognosis when identified in isolation, while others could indicate treatment resistance or progression to acute myeloid leukemia (AML). Consequently, the results must always be integrated with clinical and pathological context to guide treatment decisions effectively.
Special Instructions
Not provided.
Limitations
This FISH assay only discerns gains or losses at the EGR1, D7S486, cen 8, and PTPRT loci, and detects alterations at the KMT2A locus. It does not identify all possible rearrangements and cannot ascertain translocation partners for the KMT2A locus, which can limit the diagnostic yield.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow (Fresh)
Volume
3-5 cc
Minimum Volume
2 cc
Container
Sodium Heparin tube (green-top)
Collection Instructions
Draw bone marrow in a Sodium Heparin (green-top) tube(s).
Storage Instructions
Ship at ambient temperature (18-25°C/64-77°F) in an insulated container by overnight courier. Specimen should arrive in the laboratory within 48 hrs of collection. Do not heat or freeze.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hrs |
Other tests from different labs that may be relevant