Fluorescence in situ Hybridization (FISH), Paraffin Block
Also known as: Cytogenetics Fluorescence in situ Hybridization on Paraffin-embedded Tissue
Use
For specific FISH probe analysis of tissue specimens
Special Instructions
This test number is used for tracking FISH paraffin samples to the testing facility. Billing will occur after testing is completed. Pertinent medical findings and probe desired must accompany the request for FISH. If prior chromosome analysis has been performed, include a copy of the report. Please direct questions to genetics customer service at 800-345-4363.
Limitations
Samples fixed in formaldehyde for more than 12 hours may reduce hybridization efficiency. This test has been developed and its performance characteristics determined by LabCorp. However, it has not been cleared or approved by the FDA, as the FDA considers such clearance unnecessary for this type of clinical test. Chromosome analysis should be considered to identify clonal alterations not targeted by the FISH probes ordered.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
LOINC Codes
- 31208-2
- 62361-1
- 62360-3
- 59267-5
- 50398-7
- 48672-0
- 11502-2
Result Turnaround Time
5-7 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
One paraffin block or six 4-micron to 5-micron thick section slides
Minimum Volume
Partial paraffin block to make several slides/probe
Container
Paraffin block transport pouch
Collection Instructions
Specimen should be fixed in 10% neutral-buffered formalin or formaldehyde.
Storage Instructions
Maintain specimen at room temperature.
Causes for Rejection
Improperly embedded prep; poor fixation 72 hours; decalcified bone or bone core; broken or dirty slides; absence of tumor or quantity not sufficient for analysis