Use

Immunodiffusion test is used to detect antibodies to Histoplasma capsulatum. The antigen used is a culture filtrate. Histoplasmin H and M preciptins can be identified by the assay. The M band often appears first and may occur without the H band. M preciptin is found in about 70% of both acute and chronic histoplasmosis cases. Both M and H occur together in only about 10% of patients. Results should be interpreted in the context of clinical presentation and other laboratory findings (e.g., fungal culture).