Protein Electrophoresis, 24-Hour Urine

Also known as: Electrophoresis, Protein, 24-Hour Urine, Globulins, 24-Hour Urine

Clinical Use

Use

Evaluate myeloma, macroglobulinemia of Waldenström, lymphoma, amyloidosis; differentiate between normal renal function, glomerular proteinuria, and tubular proteinuria. Increased glomerular permeability leads to higher concentrations of large proteins in the glomerular filtrate. Diminished tubular reabsorptive capacity results in a marked increase in urinary excretion of low molecular weight problems.

Special Instructions

Not provided.

Limitations

The test might not detect pathologic light chains due to insufficient sensitivity, and should be followed with immunoelectrophoretic or immunofixation studies on concentrated urine. The optimal specimen for free monoclonal light chain detection (Bence Jones protein) is a 24-hour urine collection.

Test Details

Methodology

Other

Biomarkers

7 targets

Albumin, UAlpha-1-Globulin, UAlpha-2-Globulin, UBeta Globulin, UGamma Globulin, UM-Spike, %Total Protein, Urine

LOINC Codes

Order Codes

81231-3 - Prot Elph Pnl 24h Ur Elph

Result Codes

2888-6 - Prot Ur-mCnc
2889-4 - Prot 24h Ur-mRate
13986-5 - Albumin 24h MFr Ur Elph
13984-0 - Alpha1 Glob 24h MFr Ur Elph
13987-3 - Alpha2 Glob 24h MFr Ur Elph
13988-1 - B-Globulin 24h MFr Ur Elph
13989-9 - Gamma glob 24h MFr Ur Elph
42484-6 - M Protein 24h MFr Ur Elph
42482-0 - M Protein 24h Ur Elph-mRate

Result Turnaround Time

3-5 days

Specimen

Urine

Volume

20-mL aliquot

Minimum Volume

6-mL aliquot (Note: This volume does not allow for repeat testing.)

Container

12-mL plastic transport tube (Labcorp No. 23597) without preservative

Collection Instructions

Instruct patient to void at 8 a.m. and discard the specimen. Then collect all urine for the next 24 hours, including the 8 a.m. void the next morning. Label container with the patient's name, date and time the collection started and ended. Measure total volume. Mix well.