Protein Electrophoresis With Interpretation, 24-Hour Urine With Reflex to IFE, 24-Hour Urine

Casandra

Casandra Test Code LC06426Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 123018CPT Codes 84156, 84166

Protein Electrophoresis With Interpretation, 24-Hour Urine With Reflex to IFE, 24-Hour Urine

Also known as: Urine (24-Hour) Interpretation, Protein Electrophoresis and Reflex to IFE, 24-Hour

Clinical Use

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Use

Work up myeloma, macroglobulinemia of Waldenström, lymphoma, amyloidosis; differentiate between normal renal function, glomerular proteinuria, and tubular proteinuria. Increased glomerular permeability leads to higher concentrations of large proteins in the glomerular filtrate. Diminished tubular reabsorptive capacity results in a marked increase in urinary excretion of low molecular weight proteins.

Special Instructions

For random urine specimens, order test 003715. Ensure samples are handled according to stability requirements to avoid the need for recollection or processing errors.

Limitations

The test may not detect small M-spikes in cases where the concentration is below the sensitivity of the method. Results should be interpreted in conjunction with clinical findings, other laboratory tests, and imaging studies. Reflex testing to immunofixation (IFE) is performed at an additional charge only if an M-spike is detected, which may delay final results.

Test Details