Casandra
Casandra Test Code QD93271Version 1 (DRAFT)
Performing Lab
Cyclin D1 (BCL‑1), IHC with Interpretation
Clinical Use
Order TestUse
Approximately 65% of mantle cell lymphomas are characterized by a t(11;14)(q13;q32) translocation involving BCL‑1 that leads to deregulation of cyclin D1. Detection of cyclin D1 via immunohistochemistry is useful for identifying disease in this context.
Special Instructions
Pathology report is required. Do not freeze specimen. Setup occurs weekdays (AM) six days a week.
Limitations
Not provided.
Test Details
Methodology
Immunoassay (IHC)
Biomarkers
Cyclin D1
ProteinIHC • Expression • Ordinal Score (e.g., TPS, CPS, H-score)
Result Turnaround Time
Not provided.
Related Documents
For more information, please review the documents below
Specimen Requirements
Specimen
Tissue
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Formalin-fixed, paraffin embedded tissue block in IHC specimen transport kit; or 4‑micron unstained slides (x5) or fixed tissue in neutral buffered formalin.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Indefinite |
| Refrigerated | Indefinite |
| Frozen | Unacceptable |